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Allopurinol (trade names include Zyloprim; Allobeta; Allopurinol Mylan; Allo CT-Arzneimittel; Alloril; Apo-Allopurinol; Apurin; Milurit; Allopurinol Hexal; Progout; Allopurinol Ratiopharm; Purinase; Purinol; Allopurinol Sandoz; Urosin; Zylapour; Zyloric; Zyrik) is an anti-gout medication from preparations inhibiting uric acid production pharmacological group. This medicine is used for the treatment and prevention of gout, certain types of kidney and urinary tract stones, hyperuricosuria, to decrease high blood uric acid levels. As an enzyme blocker it works by lowering high levels of uric acid in your body by decreasing the amount produced. Allopurinol is also commonly prescribed to treat tumor lysis syndrome and to prevent high uric acid levels in patients who receive cancer chemotherapy (hyperuricemia secondary to chemotherapy). Cancer cells that are destroyed with therapy release large amounts of uric acid into the bloodstream. Also indications of this medication are include the mono- or combined therapy of patients with inflammatory bowel disease, Crohn's disease, reactive perforating collagenosis, perinatal asphyxia, reperfusion injury, epilepsy, mania, cardiothoracic surgery, heart failure, high risk of percutaneous transluminal angioplasty, leishmaniasis, and other medical conditions.
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There is an additional general information about Allopurinol (Zyloprim):
Medical and pharmaceutical categories for allopurinol:
Hyperuricemia and gout preparations
Uric acid production inhibitors
Xanthine oxidase inhibitors
The Anatomical Therapeutic Chemical (ATC) classification system allopurinol codes:
M - Musculo-skeletal system
M04 - Antigout preparations
M04A - Antigout preparations
M04AA - Preparations inhibiting uric acid production
M04AA01 - Allopurinol
M04AA51 - Allopurinol, combinations
Allopurinol in The International Statistical Classification of Diseases and Related Health Problems (ICD-10, World Health Organization) codes:
Leishmaniasis - B55
Neoplasms - C00-D49
Disorders of purine and pyrimidine metabolism - E79
Manic episode - F30
Epilepsy and recurrent seizures - G40
Heart failure - I50
Other and unspecified disorders of the circulatory system - I95-I99
Crohn's disease (regional enteritis) - K50
Ulcerative colitis - K51
Transepidermal elimination disorders - L87
Reactive perforating collagenosis - L87.1
Gout - M10
Calculus of kidney and ureter - N20
Calculus of lower urinary tract - N21
Other symptoms and signs involving the circulatory and respiratory system - R09
Asphyxia and hypoxemia - R09.0
General symptoms and signs - R50-R69
Injury of other and unspecified intrathoracic organs - S27
Other postprocedural states - Z98
Coronary angioplasty status - Z98.61
Pregnancy categories for Allopurinol (Zyloprim):
C - Australia
C - United States (Risk cannot be ruled out)
Salts and other allopurinol forms used as active pharmaceutical ingredients (API):
Synonyms of allopurinol, international and chemical names:
Best known allopurinol brands, generics and trade names in various countries:
Alfadiman - Dr. Lazar Laboratorio
Allo - AbZ-Pharma; CT-Arzneimittel; Y.S.P. Industries
Allobeta - Betapharm Arzneimittel
Allohexal - Hexal
Allonol - Ratiopharm; Utopian
Allopur - Sandoz; Ecosol; Nycomed
Allopurinol - Actavis; Apotex; Arrow Generiques; Biogaran; Drug Houses of Australia; EG Labo; Egis; Hexal; Merck; Mylan; Ranbaxy; Ratiopharm; Sandoz; Stada; Teva
Allopurinol Retard - Genericon Pharma
Alloril - Dexxon
Allostad - Stada
Allupol - Polfa Grodzisk
Allurase - Terramedic; Metro Drug Distribution
Allurit - Teofarma
Alopurinol - Sanitas Laboratorio Chimico Farmaceutico
Apo-Allopurinol - Apotex
Apurin - Novartis; Fresenius; GEA; Hexal
Atisuril - Altana Pharma
Ciploric - Cipla
Etindrax - Valdecasas Laboratorios
Gichtex Retard - Gerot Pharmazeutika
Isoric - Interbat
Lodiric - Novartis; Sandoz
Logout-SR - Inga Laboratories
Lopurin - Abbott; BASF
Loricid - Littman Drug Corp
Mephanol - Mepha; Amcron Enterprise; Ceutical Trading
Milurit - Celltech; Egis; Mekim
Novo-Purol - Novopharm
Progout - Alphapharm
Puricos - Aspen Pharmacare
Purinase - L.R. Imperial Pharmaceuticals; United Laboratories
Purinol - Carter Horner; Ratiopharm; Merckle
Reucid - Otto Pharmaceutical Industries
Soluric - Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories
Tipuric - Clonmel Healthcare
Tylonic - Metiska Farma
Unizuric - Quimica y Farmacia
Uriconorm - G. Streuli
Urosin - Roche
Xandase - Charoon Bhesaj
Xanturic - Pharmafarm Laboratoires
Zylapour - Farmanic
Zyloprim - GlaxoSmithKline
Zyloric - GlaxoSmithKline
Pharmaceutical active ingredients used in medicine in combinations with allopurinol:
Some other medications in Zyloprim (Allopurinol) pharmacological classes:
Voltaren (Diclofenac Sodium)
ALLOPURINOL (ZYLOPRIM) MEDICATION GUIDE
What is Allopurinol / Generic Zyloprim?
Allopurinol reduces the production of uric acid in your body.
Zyloprim is used to treat gout, increased levels of uric acid caused by cancer treatment, and kidney stones that are caused by high levels of uric acid.
This medication may also be used for purposes other than those listed in this medication guide.
Indications and Usage of Allopurinol
Allopurinol (Zyloprim) reduces serum and urinary uric acid concentrations. Its use should be individualized for each patient and requires an understanding of its mode of action and pharma-cokinetics. Allopurinol (Zyloprim) is indicated in:
the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy).
the management of patients with leukemia, lymphoma and malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels. Treatment with Allopurinol should be discontinued when the potential for overproduction of uric acid is no longer present.
the management of patients with recurrent calcium oxalate calculi whose daily uric acid excretion exceeds 800 mg/day in male patients and 750 mg/day in female patients. Therapy in such patients should be carefully assessed initially and reassessed periodically to determine in each case that treatment is beneficial and that the benefits outweigh the risks.
Side effects of Allopurinol (Zyloprim)
The common side effects reported with Zyloprim are diarrhea, nausea, alkaline phosphatase increase, acute attacks of gout, rash, maculopapular rash, ecchymosis, fever, headache, necrotizing angiitis, vasculitis, hepatic necrosis, granulomatous hepatitis, hepatomegaly, hyperbilirubinemia, cholestatic jaundice, vomiting, intermittent abdominal pain, gastritis, dyspepsia, myopathy, arthralgias peripheral neuropathy, neuritis, paresthesia and somnolence.
Guidelines before using Allopurinol
Zyloprim can be taken after meals to minimize gastric irritation. Allopurinol inhibits the degradation of 6-mercaptopurine and azathioprine. The concomitant administration of probencid and allopurinol should be avoided. Probencid shortens half-life of Alloxanthine (metabolite of allopurinol) and allopurinol prolongs the half-life of probencid. This medication can potentiate warfarin and theophylline by inhibiting their metabolism. The co-administration of ampicillin and Zyloprim can cause higher incidence of skin rashes. Iron therapy is not recommended during allopurinol treatment. Liberal fluid intake is advocated during therapt with this medicine. Zyloprim is contraindicated in hypersensitive patients. Allopurinol is not indicated for use during pregnancy and lactation. This drus should be cautiously used in elderly, children and in kidney or liver disease.
What are the common dosages of this medication?
The recommended starting dosage of Allopurinol is 100-200 mg daily. The maximum tolerated dose of Zyloprim is 800 mg daily.
What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.
What happens if I overdose?
Seek emergency medical attention.
Symptoms of an allopurinol overdose are not known.
What is the difference between Brand and Generic Allopurinol (Zyloprim)?
The active ingredient is allopurinol in both brand and generic forms because of which the mechanism of action and drug interactions are the same. The difference between brand and generic forms are packaging, pricing and the brand name. Generic variants are priced cheaper because there are no brand names associated with it as well as no expenses towards research and development. You can buy cheap Zyloprim medicine when it is sold as a generic variant.
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